NAD + | Belleage

NAD+

What is it?

NAD+ stands of nicotinamide adenine dinucleotide. it is a co enzyme found in every cell in the human body. it assists in converting nutrients from food into energy required for cell maintenance.

There are specific cycles that occur in our body which are necessary for human vitality. NAD+ is essential for some of these including;

Glycolysis
The Krebs cycle
The electron transport chain

In effect is transports electrons which allow the cells to produce the base form of cellular energy called ATP. This is the main energy important for health of our brain, muscles and heart cells.

In particular it is also important for both:

DNA repair
Reduction of Cellular Senescence (Aging cells)

Reduced levels are associated with both ageing and neurodegenerative processes

Research

Firstly NAD+ is not a stimulant and consumption or intravenous drips do not guarantee increased energy or longevity. The perceived effects vary in individuals.

At present there is limited research, although studies are underway. Studies have suggested:

NAD+ levels decline with age
Reduced Levels are linked with decreased mitochondrial efficiency
Restoring NAD+ levels in a animal models improves some markers of cellular function.

NAD+ comes from Vitamin B3(Niacin) which forms

Nicrotinamide
Nicotinic acid
Nicotinamide ribosome (NR)

More recently there have been instagram posts suggesting that NAD+ molecule being large does not passively transport through the cell membrane and therefore doesn't enter the cell.

Research has suggested that NAD+ levels are generally not increased by oral administration of NADH as it is not oxidised into NAD+.

Pharmacological research suggests intravenous infusions increase NAD+ levels. This may be through a special transporter on cell membrane. However this is controversial.[1]

The smaller forms of Vitamin B3 can directly pass through the membrane. In a recent clinical study about 4 months of administration of NA, the blood and muscle NAD+ level were significantlyincreased. Pilot studies have also suggested increase in NAD+. levels in plasma and extracellular tissues.[2]

1. Jing S et al, Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors, Aging and Disease, Volume 12, Number 8: 1879-1897, December 2021, http://dx.doi.org/10.14336/AD.2021.0523

2.Grant R, Berg J, Mestayer R, Braidy N, Bennett J, Broom S, Watson J. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD. Front Aging Neurosci. 2019 Sep 12;11:257. doi: 10.3389/fnagi.2019.00257. PMID: 31572171; PMCID: PMC6751327.

Side effects

When the NAD+ is injected, you can feel a bit of dizziness. and some tingling around the muscles. Ensure that you remain well hydrated before during and after the infusion

Vitamin infusions involve the intravenous administration of vitamins and minerals under the supervision of a qualified health practitioner.

The information provided on this website is general in nature and for educational purposes only. It is not intended to advertise, promote, or imply therapeutic benefit, and does not constitute medical advice.

Vitamin infusions:

Are not a substitute for a balanced diet or medical treatment
May not be suitable for everyone
Require an individual clinical assessment prior to administration
Carry potential risks and side effects, which will be discussed during consultation

The suitability, potential benefits, risks, and alternatives of any infusion can only be determined during a consultation with a qualified health practitioner, based on individual circumstances.